Cerebral infarction in a heterozygote with variant antithrombin III.
نویسندگان
چکیده
منابع مشابه
Cerebral infarction in a heterozygote with variant antithrombin III.
BACKGROUND We report a heterozygous case of familial qualitative deficiency of antithrombin III associated with cerebral infarction. CASE DESCRIPTION A 33-year-old man had a history of recurrent transient ischemic attacks from the age of 28. Cerebral computed tomography at age 29 disclosed a low-density area in the left frontal lobe, and an internal carotid angiogram showed branch occlusion o...
متن کاملCase Report Cerebral Infarction in a Heterozygote With Variant Antithrombin III
Background: We report a heterozygous case of familial qualitative deficiency of antithrombin III associated with cerebral infarction. Case Description: A 33-year-old man had a history of recurrent transient ischemic attacks from the age of 28. Cerebral computed tomography at age 29 disclosed a low-density area in the left frontal lobe, and an internal carotid angiogram showed branch occlusion o...
متن کاملProgressing ischemic stroke in a homozygote with variant antithrombin III.
A 31-year-old woman developed disturbance of consciousness and left hemiparesis. Cerebral computed tomograms showed a low-density area in the right temporal lobe that extended to the right parietal and left frontal lobes as her clinical symptoms worsened. The diagnosis of familial variant of antithrombin III (AT-III) was based on decreased biologic activity and a normal immunologic level of AT-...
متن کاملAntithrombin Milano: a new variant with monomeric and dimeric inactive antithrombin III.
A qualitative defect of antithrombin III (AT III) has been demonstrated over three generations in eight members of an Italian family by the discrepancy between a normal amount of antigen and decreased antithrombin and anti-Xa activity in the presence or in the absence of heparin. By two-dimensional immunoelectrophoresis in the absence of heparin, two peaks of AT III were present in all patients...
متن کاملAntithrombin III Nagasaki (Ser116-Pro): a heterozygous variant with defective heparin binding associated with thrombosis.
A novel variant of antithrombin III (AT III) that lacks affinity for heparin was found in a 33-year-old man who suffered from recurrent cerebral infarction. The propositus had a history of recurrent ischemic attacks from the age of 28. He was obese and had a smoking habit (30 to 40 cigarettes/day), low high-density lipoprotein cholesterol, and a mild glucose intolerance as the possible risk fac...
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ژورنال
عنوان ژورنال: Stroke
سال: 1992
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.23.12.1822